Search results for " sesquiterpene lactones"

showing 2 items of 2 documents

Cytotoxic activity of some natural and synthetic guaianolides

2005

Several natural guaianolides and synthetic derivatives of repin (1) were tested and found to be active against tumor cell replication. Repin (1) and both mono- and di-halohydrin analogues (2, 7-9, 11, 12) showed significant antitumor potency. A more effective compound (17) was obtained by esterificating repin with the paclitaxel side chain.

PaclitaxelStereochemistryPharmaceutical ScienceEpoxideSesquiterpeneAnalytical Chemistrychemistry.chemical_compoundStructure-Activity RelationshipDrug DiscoveryTumor Cells CulturedPotencyHumansCytotoxicityPharmacologychemistry.chemical_classificationMolecular StructureChemistryOrganic ChemistrySettore CHIM/06 - Chimica OrganicaAntineoplastic Agents PhytogenicIn vitroTerpenoidCentaurea Asteraceae sesquiterpene lactonesComplementary and alternative medicinePaclitaxelMolecular MedicineDrug Screening Assays AntitumorSesquiterpenesLactone
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Evaluation of the in vitro and in vivo antineoplastic effects of Parthenolide on MDA-MB231 breast cancer cells

2012

Triple-negative breast cancer refers to an aggressive subtype of breast cancer in which the tumor cells lack receptors for estrogen, progesterone and the HER2 protein on their surfaces. This type of breast cancer does not respond to treatments such as hormone therapy, like tamoxifen and aromatase inhibitors, or drugs that target HER2, like Herceptin. It is important, therefore, the identification of new selective drugs for the treatment of these tumors. Parthenolide (PN), a sesquiterpene lactone extracted from the medical plant Tanacetum parthenium, exerts anticancer activity on several tumor cell lines in culture, acting through diverse molecular mechanisms. Our previous studies have shown…

Settore BIO/10 - BiochimicaBreast cancer cells sesquiterpene lactones parthenolide DMAPT
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